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Original Article
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| Soluble urokinase plasminogen activator receptor (suPAR) is prospective biomarker to evaluate treatment progress in children with pulmonary tuberculosis during maintenance phase | ||||||
| Mardining Raras Tri Yudani1, Marrecar Aunilla Hamid2, Muhammad Slamet Chandra Kusuma3, Ery Olivianto4 | ||||||
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1Dr.rer.nat, Associate Professor, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
2MD, Master Program on Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia 3Professor, Dr, MD, Professor, Pediatric Department, Dr Saiful Anwar Hospital, Malang, Indonesia 4MD, Pediatrican, Pediatric Department Dr Saiful Anwar Hospital, Malang, Indonesia | ||||||
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| Tri Yudani MR, Hamid MA, Kusuma MSC, Olivianto E. Soluble urokinase plasminogen activator receptor (suPAR) is prospective biomarker to evaluate treatment progress in children with pulmonary tuberculosis during maintenance phase. Edorium J Pediatr 2017;1:6–11. |
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ABSTRACT
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Aims:
Childhood pulmonary tuberculosis (TB) is still a major problem in developing countries. One of the difficulty in TB management is lack of biomarkers to evaluate treatment response.This study aimed to investigate the role of plasma soluble urokinase-type plasminogen activator receptor (suPAR) as a biomarker to evaluate response to anti tuberculosis treatment in children with pulmonary TB.
Methods: Twenty five children aged 2–10 years with pulmonary TB in Dr Saiful Anwar Hospital, Malang from February 2012 to January 2013 were enrolled into the study. The plasma suPAR level was measured using ELISA prior to anti-tuberculosis treatment and two, four, six months after treatment initiation. Clinical parameters were observed including coughs, lymphadenitis, nutritional status and X-ray. Ten healthy children served as a control group. Result: All TB patients showed high plasma suPAR levels prior to anti TB treatment (4.77 +1.51 ng/mL) and did not change (p = 0.0001>0.05) after two months (4.89+1.61 ng/mL) of treatment. However, it decreased significantly after four months (2.51+1.81 ng/mL) and six months of treatment (0.27+0.64 ng/mL). By the end of therapy the level of suPAR reached a value that was lower than control group (1.58+0.09 ng/mL). The reduce of suPAR level was not parallel to clinical improvement after two months treatment. Conclusion: the suPAR level is elevated in childhood pulmonary TB and significantly decreased after four months of anti tuberculosis treatment. This imply that suPAR is not appropriate biomarker to evaluate TB treatment response in childhood TB after intensive phase of therapy. However, it is a prospective biomarker to monitor the efficacy of therapy in the maintenance phase after two months therapy. | |
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Keywords:
Biomarker, Children, Pulmonary tuberculosis, Soluble urokinase plasminogen activator receptor (suPAR)
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Acknowledgements
We thank to Fitri Armania from Laboratory Biochemistry and Molecular Biology, Faculty of Medicine, Brawijaya University for technical support. Our special gratitude to suPARnosticò, ViroGates A/S, Copenhagen, Denmark for kit discount. |
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Author Contributions
Mardining Raras Tri Yudani – Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Marrecar Aunilla Hamid – Acquisition of data, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Muhammad Slamet Chandra Kusuma – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published Ery Olivianto – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2017 Mardining Raras Tri Yudani et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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